Why is Vitalast now offering a version of NewVigor with LJ100® instead of deer antler velvet?

NewVigor with Deer Antler Velvet has been a popular product for over a decade... so why are we making this change?

Two reasons.

First, deer antler velvet from our preferred sources has become increasingly hard to get.

And second, possibly related to that, is that there have been reports of covid infections in the deer population. DON'T WORRY... All NewVigor deer antler velvet product EVER manufactured has used deer antler velvet that was harvested before covid even existed! However, this has become an issue moving forward, as product from that time is no longer available for future manufacturing, and we felt that, for now, the most prudent thing to do would be to reformulate without deer product. Existing inventory already manufactured will be available probably for the rest of 2022.

In the mean time, in our quest for an alternate formulation, we settled on LJ100, a patented, clinically proven extract of Eurycoma longifolia (also known as Tongkat Ali, though harvested and manufactured to particular specifications). All other NewVigor ingredients remain the same as in our deer antler velvet product, only this one ingredient is different between the two versions. While many long time NewVigor customers are well aware of how well NewVigor with deer antler velvet has worked for them, there was little in the way of clinical evidence. LJ100 actually has a lot more scientific research behind it, so we are optimistic that people will find this new formulation to work just as well if not better!

So what ARE some of the clinically proven benefits of LJ100?

We're glad you asked! Below are summaries of a series of studies related to sexual health, supplied by the manufacturer. And as a bonus, additional studies showed evidence of benefits in the areas of reduced body fat and general weight management, mood/stress management, muscle strength, too!


1. ANDROPAUSE: THE ELEPHANT IN THE ROOM

“Andropause,” often called “male menopause,” is not a marketing term or a buzzword. It is a highly accurate description of a condition marked and exacerbated by a slow but steady decline in endogenous testosterone production. Low testosterone levels give rise to several quality of life issues, including:

• fatigue
• reduced muscle bulk/strength
• low mood/depression
• fewer spontaneous erections
• loss of libido
• decreased ability to concentrate
• increased body fat

The difference between andropause and menopause is that the former is characterized by gradual declines in hormone levels, while in women, hormone levels drop suddenly. Healthy men will usually experience a 1% drop in testosterone every year starting around age 40. Young men typically have testosterone levels of approximately 1,000 ng/dl, while the average level for an 80-year-old man is about 200 ng/dl. Referring back to the testosterone saliva test in the previous chapter, the starting ng/dl levels of men in various age brackets are about normal. The oldest volunteer, age 52, achieved a 70% increase in testosterone after LJ100® consumption, peaking at 765 ng/dl at the study’s conclusion.

Researchers George and Henkel explain in their January 2014 paper published in Andrologia, “Testosterone deficiency syndrome (TDS) is characterized by numerous symptoms, including low libido, increased fat mass, fatigue, erectile dysfunction or osteoporosis, and up to 80% of men will experience some kind of ageing males’ symptoms. This is caused by the age-depending decline in serum testosterone levels with concentrations being about 40–50% lower in men older than 60 years compared with young men. This significant decline in testosterone levels is further closely linked with medical conditions such as obesity, metabolic syndrome, diabetes or hypertension. The conventional way of treating TDS is the testosterone replacement therapy (TRT), for which preparations are on the market. Apart from the beneficial effects of TRT, significant adverse side effects have been described, and prostate cancer (PCa) as absolute contraindication is debated” (12).

They add that LJ100® is a “natural alternative to TRT and has been shown to restore serum testosterone levels, thus significantly improving sexual health. This includes significant positive effects on bone health and physical condition of patients. In addition, a significant antihyperglycemic effect and cytotoxicity against PCas cells has been shown. Thus far, at therapeutic concentrations, no significant side effects of the treatment were obvious. Therefore, TA might be a safe alternative to TRT” (12).

Late-onset hypogonadism (LOH) is defined by reduced serum testosterone levels (either total testosterone or free testosterone). For many older men, this status can cause detrimental physiological issues, as well as depression. One study published in the First International Journal of Andrologia (2011) investigated the effects of LJ100® in this population (13).

In the study, 76 men with LOH were given 200 mg of LJ100® for one month. LJ100® significantly improved AMS scores. AMS scores improved from 10.5% at the study’s onset to 70.1% at its conclusion. Serum testosterone rose from 5.66 nm to 8.31 nm (46.82% increase). The percentage of men with testosterone levels in normal ranges at the study’s beginning was 35.5%; this increased to 90.8% after one month of daily LJ100® supplementation. Thus, LJ100® appears to be useful as a supplement in overcoming the symptoms of LOH and for the management of hypogonadism.

In a 2002 study presented at the First Asian Andrology Forum in Shanghai, China, 30 male patients took 100 mg of LJ100® for three weeks; Partial Androgen Deficiency In Aging Men (PADAM) scores improved by 82%, suggesting significant improvement in physical, vasomotor, psychological and sexual wellbeing. DHEA increased from 26% to 47%, SHBG decreased from 36% to 66% of subjects. Consequently, free testosterone levels increased from 39% to 73% in the LJ100® group (1).

In another study published in the International Journal of Andrology (2005), 20 male volunteers of various health conditions from the ages of 38 to 58 were randomly given either 200, 400, 600 mg of LJ100® or placebo for two months. The LJ100® group showed improvement in Sexual Health Inventory for Men, improvement in sexual desires and performance. Aging Males’ Score also showed improvement in sexual, physical, psychology and vasomotor domain.  Testosterone and DHEA levels showed high normal levels when compared to baseline. In addition, LJ100® group were found to have high normal level of IGF-1 compared to placebo (17).


2. SEXUAL PERFORMANCE AND WELL-BEING IN MEN

Effects of a Proprietary Freeze-Dried Water Extract of Eurycoma longifolia (LJ100/Physta) and Polygonum minus on Sexual Performance and Well-Being in Men: A Randomized, Double-Blind, Placebo-Controlled Study

Jay K. Udani Annie A. George  Mufiza Musthapa
Michael N. Pakdaman and Azreena Abas

1. Medicus Research LLC, Northridge, CA 91325, USA

2. Northridge Hospital Integrative Medicine Program, Northridge, CA 91325, USA

LJ100/Physta is a proprietary product containing a freeze-dried water extract of Eurycoma longifolia (tongkat ali), which is traditionally used as an energy enhancer and aphrodisiac. We aim to evaluate a 300 mg combination of LJ100/Physta and Polygonum minus, an antioxidant, with regard to sexual performance and well-being in men.


Methods
. Men aged 40–65 years were screened for this 12-week randomized, double-blind, placebo-controlled, parallel-group study. Outcome measures included validated questionnaires that aimed to evaluate erectile function, satisfaction with intervention, sexual intercourse performance, erectile hardness, mood, and overall quality of life.

Results
. 12 subjects in the active group and 14 in the placebo group completed the study. Significant improvements were noted in scores for the Sexual Intercourse Attempt diary, Erection Hardness Scale, Sexual Health Inventory of Men, and Aging Male Symptom scale (𝑃 < 0.05 for all). Three adverse events were reported in the active group and four in the placebo group, none of which were attributed to study product. Laboratory evaluations, including liver and kidney function testing, showed no clinically significant abnormality. 

Conclusion
. Supplementation for twelve weeks with Polygonum minus and the proprietary Eurycoma longifolia extract, LJ100/Physta, was well tolerated and more effective than placebo in enhancing sexual performance in healthy volunteers.
3. ENDURANCE

Effect of Eurycoma longifolia Extract on Anabolic Balance During Endurance Exercise

Talbott S, Talbott J, Negrete J, Jones M, Nichols M, and Roza J. SupplementWatch, Inc. Draper, UT

Background. 
Eurycoma longifolia, commonly known as “Tongkat Ali” or “Longjack,” is often touted as a testosterone “booster” and marketed to athletes as a training aid and performance enhancer. Rodent studies have shown oral delivery of Eurycoma extract to improve sexual performance and increase serum testosterone levels. Open-label human trials have suggested that Eurycoma extract may help prevent age-associated androgen deficiency, improve sexual function, and increase psychological parameters such as mood, energy, and sense of well-being.

Purpose.
 The purpose of this study was to determine the effects of Eurycoma longifolia on testosterone and cortisol levels during intense endurance exercise.

Methods.
 We used a water-soluble extract of Eurycoma longifolia (E) standardized to 22% eurypeptides and 40%
glycosaponins. Male subjects (N=30) were recruited from a 24-hour mountain biking event and asked to provide a saliva sample before and after each lap for measurement of cortisol and testosterone by enzyme immunoassay (Salimetrics, State College, PA). Subjects completed 4 laps (14.91 miles/lap) and provided 8 saliva samples over a 24h period. Subjects consumed 100mg of E (N = 15) or a look-alike placebo (P, N = 15) approximately 30 minutes prior to endurance exercise.

Results. 
Cortisol levels were 32.3% lower in E compared to P (0.552+0.665 versus 0.816+0.775 ug/dL, P < 0.05). Testosterone levels were 16.4% higher in E compared to P (86.72+40.90 versus 72.47+33.77 pg/mL, P < 0.05). 

Conclusions.
 These results suggest that Eurycoma longifolia extract may help to maintain normal levels of cortisol (low) and testosterone (high) and thus promote an overall “anabolic” hormonal state (versus a “catabolic” state characterized by elevated cortisol and suppressed testosterone) during intense endurance exercise.

4. MALE LIBIDO


Shaiful Bahari Ismail,1 Wan Mohd Zahiruddin Wan Mohammad, Annie George,

Nik Hazlina Nik Hussain, Zatul Mufiza Musthapa Kamal, and Eckehard Liske

1. School of Medical Sciences, Universiti Sains Malaysia

2. Department of Science and Clinical Trial, Biotropics, Malaysia

3. Department of Life Sciences, Technical University of Braunschweig, Germany



Eurycoma longifolia is reputed as an aphrodisiac and remedy for decreased male libido. A randomized, double-blind, placebo controlled, parallel group study was carried out to investigate the clinical evidence of E. longifolia in men. The 12-week study in


109 men between 30 and 55 years of age consisted of either treatment of 300 mg of water extract of E. longifolia (LJ100/Physta) or placebo. Primary endpoints were the Quality of Life investigated by SF-36 questionnaire and Sexual Well-Being investigated by International Index of Erectile Function (IIEF) and Sexual Health Questionnaires (SHQ); Seminal Fluid Analysis (SFA), fat mass and safety profiles. Repeated measures ANOVA analysis was used to compare changes in the endpoints.


The E. longifolia (EL) group significantly improved in the domain Physical Functioning of SF-36, from baseline to week 12 compared to placebo (P = 0.006) and in between group at week 12 (P = 0.028). The EL group showed higher scores in the overall Erectile Function domain in IIEF (P<0.001), sexual libido (14% by week 12), SFA- with sperm motility at 44.4%, and semen volume at 18.2% at the end of treatment. Subjects with BMI ≥ 25 kg/m2 significantly improved in fat mass lost (P = 0.008). All safety parameters were comparable to placebo.